Clear the board one colour group at a time, and make every move count.
Click any group of two or more touching pieces of the same colour to clear it. The pieces above drop down, empty columns slide together, and the board changes with every move. A group of n pieces scores (n − 2)², so patience pays: one group of 20 scores 324, but four groups of 5 score just 36. Clear every last piece for a 1,000 point bonus.